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Compounding Pharmacy Causes Fungal Eye Infections

A single compounding pharmacy is responsible for two simultaneous outbreaks of fungal endophthalmitis caused by contamination with Fusarium mold in "sterile" Brilliant Blue G dye (BBG) made by Franck's Compounding Pharmacy located in Ocala, Florida. Nine cases of fungal endophthalmitis were initially reported from the contaminated BBG. When the Center for Disease Control (CDC) investigated these fungal infections, it also found that another Franck product, triamcinolone acetonide for intravitreal injection, was contaminated with Fusarium mold, bringing the total of cases to 47 in 9 states. A second fungus, Bipolaris mold, was also found in the products. The rarity of these infections in these outbreaks provided the clue to prompt an investigation by health authorities.

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