Ectopic pregnancies can cause catastrophic injuries to women when they go undiagnosed and massive hemorrhage results threatening future fertility and survival. Timely diagnosis in stable patients remains a challenge. Early detection lowers the morbidity and mortality associated with tubal rupture or spontaneous abortion. Unfortunately, approximately 40% of women with ectopic pregnancies are not diagnosed when they first present with symptoms of abdominal pain or vaginal bleeding. A recent study in the Journal of the American Medical Association (JAMA) looked at the clinical tools for assessing women with possible ectopic pregnancy at an early stage before life threatening hemorrhage occurs.